2.3 OVAL SQUARE OVAL OVAL OVAL OVAL OVAL SQUARE SQUARE OVAL SQUARE inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive active inactive active inactive inactive active inactive inactive active inactive inactive inactive active inactive active inactive active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active active active inactive active inactive inactive inactive active active active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive active inactive active active inactive inactive inactive inactive active inactive inactive active inactive inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive active active active active inactive inactive inactive inactive inactive active active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active active active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive active active inactive inactive active inactive inactive active active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active inactive inactive inactive active inactive active inactive active inactive active inactive active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive active active inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive active active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active active active inactive inactive active inactive active inactive inactive inactive inactive inactive active active inactive active inactive inactive active active inactive inactive inactive active inactive inactive inactive active active active inactive inactive active inactive inactive active inactive inactive active ER lipid droplet Golgi lysosome vesicle nucleus mitochondria macrophage inside PROTEIN p2 inside DEGRADED a13_degraded inside PROTEIN p20 inside PROTEIN p22 inside SIMPLE_MOLECULE LPA inside PROTEIN p26 inside SIMPLE_MOLECULE UDP inside SIMPLE_MOLECULE UTP inside SIMPLE_MOLECULE cAMP inside SIMPLE_MOLECULE PI4,5-P_sub_2 inside SIMPLE_MOLECULE DAG inside SIMPLE_MOLECULE IP3 inside SIMPLE_MOLECULE sphingosine inside SIMPLE_MOLECULE cAMP PROTEIN p42 inside PROTEIN p42 PROTEIN p43 inside PROTEIN p1 transmembrane PROTEIN p40 transmembrane PROTEIN p40 transmembrane PROTEIN p45 transmembrane PROTEIN p45 transmembrane PROTEIN p46 inside PROTEIN p47 inside PROTEIN p51 inside SIMPLE_MOLECULE ADPR inside SIMPLE_MOLECULE cADPR inside PROTEIN p49 inside PROTEIN p49 PROTEIN p48 inside PROTEIN p49 PROTEIN p48 transmembrane PROTEIN p50 PROTEIN p46 inside SIMPLE_MOLECULE cADPR PROTEIN p50 inside PROTEIN p53 inside SIMPLE_MOLECULE GDP PROTEIN p55 inside SIMPLE_MOLECULE GTP PROTEIN p55 inside PROTEIN p59 inside PROTEIN p59 inside PROTEIN p61 inside PROTEIN p61 inside SIMPLE_MOLECULE 1-O-alkyl-glycero-_br_phosphocholin inside SIMPLE_MOLECULE lyso-PAF inside PROTEIN p62 inside PROTEIN p62 inside PROTEIN p66 inside PROTEIN p69 inside PROTEIN p72 inside PROTEIN p71 PROTEIN p69 inside PROTEIN p72 PROTEIN p70 inside PROTEIN p70 transmembrane PROTEIN p71 PROTEIN p72 PROTEIN p69 PROTEIN p70 transmembrane PROTEIN p71 PROTEIN p72 PROTEIN p69 PROTEIN p70 inside PROTEIN p77 inside PROTEIN p77 2 inside SIMPLE_MOLECULE PI3,4,5-P_sub_3 inside PROTEIN p78 inside DEGRADED a295_degraded inside PROTEIN p81 inside PROTEIN p89 inside PROTEIN p90 inside GENE SOCS3 inside PROTEIN p96 inside PROTEIN p97 inside PROTEIN p94 inside PROTEIN p71 PROTEIN p94 inside PROTEIN p88 PROTEIN p94 transmembrane PROTEIN p71 PROTEIN p88 PROTEIN p94 PROTEIN p94 transmembrane PROTEIN p71 PROTEIN p88 PROTEIN p94 PROTEIN p94 inside PROTEIN p99 inside SIMPLE_MOLECULE LPS inside PROTEIN p102 inside PROTEIN p109 transmembrane PROTEIN p98 transmembrane PROTEIN p102 PROTEIN p99 inside PROTEIN p103 inside PROTEIN p111 PROTEIN p112 inside PROTEIN p104 inside GENE IFN-_beta inside PROTEIN p113 inside PROTEIN p116 inside PROTEIN p118 inside PROTEIN p125 innerSurface SIMPLE_MOLECULE sphingomyelin inside SIMPLE_MOLECULE ceramide transmembrane PROTEIN p114 PROTEIN p129 inside PROTEIN p115 inside PROTEIN p117 transmembrane PROTEIN p117 PROTEIN p115 PROTEIN p129 transmembrane PROTEIN p118 PROTEIN p129 inside PROTEIN p132 inside PROTEIN p131 inside PROTEIN p131 inside DEGRADED a615_degraded inside PROTEIN p130 inside GENE IL-10 inside GENE IL-6 inside GENE IL-1 inside GENE NF-_kappa_ B inside GENE I_kappa_ B inside GENE TNF_alpha outerSurface PROTEIN p133 inside PROTEIN p130 inside PROTEIN p137 inside PROTEIN p138 inside PROTEIN p135 inside PROTEIN p135 PROTEIN p71 inside PROTEIN p135 PROTEIN p83 transmembrane PROTEIN p71 PROTEIN p83 PROTEIN p135 PROTEIN p135 inside PROTEIN p139 transmembrane PROTEIN p135 PROTEIN p135 PROTEIN p83 PROTEIN p71 inside PROTEIN p135 PROTEIN p135 PROTEIN p83 PROTEIN p71 PROTEIN p92 inside PROTEIN p142 inside PROTEIN p145 inside PROTEIN p147 inside PROTEIN p148 inside PROTEIN p141 inside PROTEIN p141 PROTEIN p71 inside PROTEIN p140 PROTEIN p88 inside PROTEIN p140 transmembrane PROTEIN p141 PROTEIN p140 PROTEIN p71 PROTEIN p88 transmembrane PROTEIN p141 PROTEIN p140 PROTEIN p71 PROTEIN p88 inside PROTEIN p142 inside GENE IRF-1 inside GENE IRF-2 inside GENE IFN-_alpha inside GENE NOSII/iNOS inside GENE IRF-7 inside GENE IRF-9 inside SIMPLE_MOLECULE G6P inside SIMPLE_MOLECULE F6P inside SIMPLE_MOLECULE F1,6-bisP inside SIMPLE_MOLECULE GA3P inside SIMPLE_MOLECULE DHAP inside SIMPLE_MOLECULE 1,3-bisP glycerate inside SIMPLE_MOLECULE 3P glycerate inside SIMPLE_MOLECULE 2P glycerate inside SIMPLE_MOLECULE PEP inside SIMPLE_MOLECULE glucose transmembrane PROTEIN p149 inside PROTEIN p150 inside PROTEIN p151 inside PROTEIN p152 inside PROTEIN p153 inside PROTEIN p154 inside PROTEIN p155 inside PROTEIN p156 inside PROTEIN p157 inside PROTEIN p158 inside PROTEIN p159 inside SIMPLE_MOLECULE isocitrate inside SIMPLE_MOLECULE _alpha_ -krtoglutarate inside SIMPLE_MOLECULE succinyl CoA inside SIMPLE_MOLECULE succinate inside SIMPLE_MOLECULE fumarate inside PROTEIN p160 inside PROTEIN p161 inside PROTEIN p162 inside PROTEIN p163 inside PROTEIN p164 inside PROTEIN p165 inside PROTEIN p166 inside PROTEIN p168 transmembrane PROTEIN p171 inside PROTEIN p169 inside PROTEIN p169 inside SIMPLE_MOLECULE malonyl CoA transmembrane PROTEIN p172 inside PROTEIN p173 transmembrane PROTEIN p174 inside PROTEIN p175 inside PROTEIN p176 inside PROTEIN p177 inside PROTEIN p178 inside PROTEIN p179 inside SIMPLE_MOLECULE glycerol 3P inside SIMPLE_MOLECULE O_sub_2_endsub_ inside SIMPLE_MOLECULE hypoxanthine inside SIMPLE_MOLECULE xanthine inside SIMPLE_MOLECULE LOH inside SIMPLE_MOLECULE GSSG inside SIMPLE_MOLECULE GSH inside ION Fe_super_2+_endsuper_ inside ION Cl_super_-_endsuper_ inside SIMPLE_MOLECULE LOOH inside ION Fe_super_3+_endsuper_ inside SIMPLE_MOLECULE L-arginine inside SIMPLE_MOLECULE citrulline inside SIMPLE_MOLECULE ONOO_super_-_endsuper_ inside SIMPLE_MOLECULE HOCl innerSurface PROTEIN p189 inside GENE ABCA1 inside GENE CD36 inside SIMPLE_MOLECULE 27-hydroxyChol PROTEIN p193 PROTEIN p192 SIMPLE_MOLECULE 9-cis_br_retinoic acid inside GENE LXR_alpha_ inside GENE SREBP1c inside SIMPLE_MOLECULE 9-cis_br_retinoic acid inside SIMPLE_MOLECULE 27-hydroxyChol inside PROTEIN p191 PROTEIN p192 inside PROTEIN p193 PROTEIN p192 transmembrane PROTEIN p199 PROTEIN p200 inside UNKNOWN ? inside PROTEIN p203 transmembrane PROTEIN p199 PROTEIN p204 PROTEIN p200 inside SIMPLE_MOLECULE propeptide inside GENE acetyl CoA carboxylase inside GENE fatty acid synthetase inside GENE acyl CoA synthetase inside SIMPLE_MOLECULE 5-hydroperoxy-_br_eicosatetraenoic acid inside SIMPLE_MOLECULE LTA_sub_4 inside SIMPLE_MOLECULE glutathione inside SIMPLE_MOLECULE glutamic acid inside SIMPLE_MOLECULE LTD_sub_4 inside SIMPLE_MOLECULE glycine inside SIMPLE_MOLECULE LTE_sub_4 inside SIMPLE_MOLECULE PGH_sub_2 inside SIMPLE_MOLECULE PGG_sub_2 inside PROTEIN p209 inside PROTEIN p210 insi